Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer

Exacerbated experimental colitis in TNFAIP8-deficient mice.

The TNF-α-induced protein 8 (TNFAIP8 or TIPE) is a risk factor for cancer and bacterial infection, and its expression is upregulated in a number of human cancers. However, its physiologic and pathologic functions are unclear. In this study, we describe the generation of TIPE-deficient mice and their increased sensitivity to colonic inflammation. TIPE-deficient mice were generated by germ line g...

Microsatellite instability in colitis associated colorectal cancer

Microsatellite instability in colitis associated colorectal cancer As molecular pathways of colon carcinogenesis continue to be defined for high risk hereditary colon cancer syndromes and for average risk sporadic colon cancers, it seems that colon carcinogenesis in the setting of chronic idiopathic inflammatory bowel disease (IBD) may be unique. 1 Although to some extent this notion seems intu...

Microsatellite instability in colitis associated colorectal cancer.

Microsatellite instability in colitis associated colorectal cancer

Microsatellite instability in colitis associated colorectal cancer As molecular pathways of colon carcinogenesis continue to be defined for high risk hereditary colon cancer syndromes and for average risk sporadic colon cancers, it seems that colon carcinogenesis in the setting of chronic idiopathic inflammatory bowel disease (IBD) may be unique. 1 Although to some extent this notion seems intu...

Colorectal Cancer Associated with Strongyloides stercoralis Colitis

Strongyloides stercoralis colitis is a severe but easily curable disease with a high mortality rate if left untreated. Strongyloidiasis can persist up to several decades and may lead to a chronic colitis similar to that seen in inflammatory bowel disease (IBD), and the two are often confused. Chronic colitis from IBD is associated with an increased risk of colorectal cancer, so it is plausible ...